The following clients are supported for Exchange 2016
Automatic configuration through Autodiscover is Microsoft's primary mechanism for Outlook configuration and is preferred. Autodiscover is also used after the initial configuration of Outlook to periodically poll Exchange for any configuration changes.
Autodiscover attempts a DNS query for "_autodiscover._tcp.[Domain name]" . If your domain name is registered with our nameservers then the Autodiscover record will automatically be configured.
If you use 3rd party nameservers please ensure the following SRV record is created:
Service: _autodiscover
 Protocol: _tcp
 Server: cluster1.exchange.outitgoes.com.
 Port: 443
 Priority: 0
 Weight: 0
Manual configuration is only be an option for Outlook 2013 or older. 2016 + clients are entirely dependent on Autodiscover. When Automatic configuration is no longer an option, attempt the following:
You can now open Microsoft Outlook and select your new profile from those presented in the dropdown.
Outlook will immediately prompt you for your password - be sure to double check your email address in the top field at this time also. Enter your password carefully and check "Remember my password". Outlook will then start to sync with Exchange.
A variety of tests can be performed at testconnectivity.microsoft.com to provide detailed output of where a failure might be.
											  Article ID: 711
											  Created On: Wed, Oct 3, 2018 at 1:51 PM
											  Last Updated On: Wed, Oct 3, 2018 at 1:51 PM
											  
											
Online URL: https://www.heartinternet.uk/support/article/how-do-i-set-up-my-email-client-for-exchange-2016.html